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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AP4E1 All Species: 17.88
Human Site: T291 Identified Species: 43.7
UniProt: Q9UPM8 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPM8 NP_031373.2 1137 127287 T291 L G K D D Q R T S E L M Y D V
Chimpanzee Pan troglodytes XP_001169245 1137 127426 T291 L G K D D Q R T S E L M Y D V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535479 1138 127884 T291 L G K D D Q R T S E L M Y D V
Cat Felis silvestris
Mouse Mus musculus Q80V94 1122 124787 T290 L G K D D E R T S E L M Y D V
Rat Rattus norvegicus P18484 938 104026 G129 S R N P T F M G L A L H C I A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_699042 1121 123888 T284 L G R D D Q S T S E L M Y E V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91926 940 105602 L131 P V H V N L A L Q C I A N I G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002328755 980 107167 E171 E L L G H S K E A V R K K A I
Maize Zea mays NP_001169710 969 105519 P160 E A I P A V L P Q V V E L L A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12028 832 93606 A23 K T L A D E R A I I T K Q S A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 N.A. 91.7 N.A. 79.9 20.7 N.A. N.A. N.A. N.A. 54.1 N.A. 21.5 N.A. N.A. N.A.
Protein Similarity: 100 99.6 N.A. 95.5 N.A. 87.6 41.1 N.A. N.A. N.A. N.A. 71.6 N.A. 42.2 N.A. N.A. N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 93.3 6.6 N.A. N.A. N.A. N.A. 80 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 6.6 N.A. N.A. N.A. N.A. 93.3 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: 31.4 30.4 N.A. N.A. 20.9 N.A.
Protein Similarity: 49 48.7 N.A. N.A. 38.6 N.A.
P-Site Identity: 0 0 N.A. N.A. 13.3 N.A.
P-Site Similarity: 20 6.6 N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 10 10 0 10 10 10 10 0 10 0 10 30 % A
% Cys: 0 0 0 0 0 0 0 0 0 10 0 0 10 0 0 % C
% Asp: 0 0 0 50 60 0 0 0 0 0 0 0 0 40 0 % D
% Glu: 20 0 0 0 0 20 0 10 0 50 0 10 0 10 0 % E
% Phe: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 50 0 10 0 0 0 10 0 0 0 0 0 0 10 % G
% His: 0 0 10 0 10 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 10 10 10 0 0 20 10 % I
% Lys: 10 0 40 0 0 0 10 0 0 0 0 20 10 0 0 % K
% Leu: 50 10 20 0 0 10 10 10 10 0 60 0 10 10 0 % L
% Met: 0 0 0 0 0 0 10 0 0 0 0 50 0 0 0 % M
% Asn: 0 0 10 0 10 0 0 0 0 0 0 0 10 0 0 % N
% Pro: 10 0 0 20 0 0 0 10 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 40 0 0 20 0 0 0 10 0 0 % Q
% Arg: 0 10 10 0 0 0 50 0 0 0 10 0 0 0 0 % R
% Ser: 10 0 0 0 0 10 10 0 50 0 0 0 0 10 0 % S
% Thr: 0 10 0 0 10 0 0 50 0 0 10 0 0 0 0 % T
% Val: 0 10 0 10 0 10 0 0 0 20 10 0 0 0 50 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 50 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _